Supreme Pharmacist System

Chapter 156 Mutation Breeding

Hearing Zhou Wen's words, Zhu Linqing said "Oops" in his heart.

Hearing what the other party meant, it was clear that a CRO company offered more favorable terms.

After hanging up the phone, Zhu Linqing looked at the new version of the patented technical description of sildenafil granules on the computer, and couldn't help frowning.

Although the conditions offered by Yao Ming Apprentice are harsh, they can be regarded as "conscience prices" in the industry. Generally, CRO companies really dare not say that they can compare with the conditions offered by Yao Ming Apprentice.

Since this CRO company dared to grab food from a tiger's mouth, it must have seen the huge market potential of this drug.

Even, sildenafil granules have been made in advance according to the technological process, and preliminary clinical trials have been done, and the efficacy of the drug is very significant, so they can't wait to cooperate with Zhou Wen.

After some analysis, Zhu Linqing believed that his guess should not be far from the truth.

Thinking of this, he immediately picked up the phone and called the laboratory.

"Hey, Director Shao, I sent a file to your email. You follow the technical process above and make it for me as soon as possible. I will get the drug efficacy evaluation report within 48 hours."

two days later...

Zhu Linqing got the drug efficacy test report.

Skim through the previous toxicology test data reports and see the results directly.

Number of people participating in internal testing: 6.

2 had mild ED, 2 had moderate ED, and 2 had severe ED.

According to the test, the new version of sildenafil granules has a particularly significant effect on the treatment of ED symptoms. The 6 participants in the test all have very impressive data...

Looking at the test report, Zhu Linqing felt regretful.

With such a drug effect, if the side effects are not too obvious in clinical trials, it is almost a 100% thing to replace the old sildenafil tablets after it goes on the market.

"No, I can't just give up like this..."

Zhu Linqing immediately decided to have a detailed interview with Zhou Wen.

No matter how bad it is, you have to find the company that cut off the beard and get a share of it.

...

On the other side, Xu Yuting came to Jiangzhou on the afternoon of the 30th.

At three o'clock in the afternoon on December 31, I met Zhou Wen in the office of Hengfeng Building in Jinhu District.

Exceptionally, Chen Zhiyuan and the lawyers of both parties were also present.

"Hello Mr. Xu~"

"Hehe, hello~"

While shaking hands, the two looked at each other closely.

In Zhou Wen's eyes, Xu Shuangyu's sister-in-law has an outstanding demeanor and elegant temperament, and she is different from the so-called strong women. Xu Yuting is full of the personal charm of a female entrepreneur, which makes people like her very much.

From Xu Yuting's point of view, Zhou Wen looked much more real than the radiant young genius on the podium.

"This is Chen Zhiyuan, the general manager of Huanyu."

"Hello, Mr. Chen."

"Hi Mr. Xu, please sit down."

"OK, all right……"

Xu Yuting is a standard businessman, and Zhou Wen is also thinking about how to maximize the benefits of patents.

So there was not too much politeness, after a few simple greetings, they got straight to the point.

In fact, Xu Shuangyu had already outlined Longkang's conditions before.

Zhou Wen authorized Longkang to license the new sildenafil granules, and Longkang was responsible for the promotion and operation.

Everyone earns 19% of the money earned.

Longkang is 90% and Zhou Wen is 10%.

Don't get excited yet.

Zhou Wen's 10% is 10% of the total sales.

Remember, it's "sales."

That is to say, if the new version of sildenafil granules is on the market,

With annual sales of 1 billion, Zhou Wen will get 100 million.

Ten billion is a billion.

Although Longkang Group took 90% of the money, they were responsible for clinical trials, new drug listing applications, and promotion and sales of the 90%.

Secondly, the profits of downstream dealers are divided into these, which are also deducted from the 90%, so in fact, the profits obtained by Longkang will be greatly diluted.

In addition, the two parties also have a guarantee agreement.

After signing the agreement, regardless of whether the sildenafil granules can be launched or not, and how the sales after the launch will be, Zhou Wen must pay a patent fee of 20 million (included in sales) every year.

Because of this, after excluding all costs, Longkang basically made no money in the first three years. And not making money means losing money.

So Longkang is betting on the later market.

Win the young model in the clubhouse, lose and go to work in the sea.

Xu Yuting and Zhou Wen discussed some details of the contract, but the overall direction remained unchanged.

After researching and discussing for half an hour, Chen Zhiyuan formally signed the authorization contract with Longkang on behalf of Zhou Wen.

The authorized subject of Zhou Wen's side is not him personally, but Huanyu Biotechnology Co., Ltd.

Because he is a technical shareholder, he has already handed over the patent right to Huanyu Biotechnology Co., Ltd., and then authorized it to Longkang Group by Huanyu Biotechnology Co., Ltd.

After the renegotiation of the back shares, the patent rights will be changed to the main body of the company.

This will not only improve the company's intangible assets and corporate image, but also involve applying for government projects, patent funding, and reasonable tax avoidance, etc...

In short, there are many benefits.

"Mr. Xu, happy cooperation."

"Happy cooperation~ After New Year's Day, the 20 million guaranteed patent fee will be transferred to Huanyu Company's account first."

"OK, all right……"

Then Zhou Wen sent Xu Yuting downstairs.

At the entrance of the company building, Xu Yuting suddenly smiled and said, "By the way, Pisces will return to China next week."

While speaking, Xu Yuting watched Zhou Wen's expression.

Zhou Wen laughed and said, "Well, she told me that I will treat her to dinner when I come back."

Xu Yuting didn't see anything on Zhou Wen's face, she showed a bright smile and said, "Then I'll go first."

"Okay, Mr. Xu, go slowly..."

Zhou Wen watched Xu Yuting's Spinner start slowly, and then disappeared from sight.

He turned and went upstairs, took some things and prepared to leave.

Chen Zhiyuan came over and said with a smile: "Hey Lao Zhou, last time that Xiao Min kept asking me why your phone couldn't get through, did you block her?"

Zhou Wen said, "No, I just reported a random number."

Chen Zhiyuan bared his teeth and said, "Awesome~ You have initially grasped the essence of not taking the initiative, not refusing, and being irresponsible."

"Get out~ It's because of you bastard, I'm so depraved now."

"Don't say that. Everyone has the love of beauty. At most, it is a little bit of fraternity. How can it be called depravity?"

"Okay, okay, go on to Bo'ai. I'm going to the laboratory~"

Zhou Wen took the car keys and prepared to leave.

Chen Zhiyuan said: "Lend me your car, I'll meet a client later~ My car is too bad."

"Then give me your car." Saying that, Zhou Wen threw the keys to Chen Zhiyuan.

Chen Zhiyuan spread his arms and said, "I lent my car to someone in the company to do business."

Zhou Wen said speechlessly, "Then what the hell am I driving?"

Chen Zhiyuan laughed and said, "You drive a Ferrari. A car worth tens of millions can't just be thrown into the garage every day for ashes."

Zhou Wen: "Then how can I drive to the laboratory?"

"Why don't I borrow an electric car from Xiao Liu at the front desk for you to drive?"

"Get out~"

"Hey, okay." Chen Zhiyuan took the key and walked away.

"Show the bag, let's show the bag." Zhou Wen didn't bother to call Didi, took the key of the Ferrari F12tdf from the office and went downstairs.

...

Huanyu Biotechnology Research Institute, No. 404, Industrial Park, Jinhu District.

In the open office, seven or eight people, including Wang Hua, Sun Xin, Song Xuezhang, Bai Xuan, and Luo Chunlei, were studying and discussing together.

This is the person in charge selected by many doctors themselves. They are very good in character and academics, and they also have certain leadership skills.

Everyone agrees.

And the technology they are discussing at this time is "mutation breeding", which is one of the projects that Huanyu will focus on in the next step.

The so-called mutation breeding technology is actually similar to the genetic modification technology of rice aphids that Zhou Wen studied before.

It is to use physical, chemical and other factors under artificial conditions to induce mutations in organisms, select from them, and cultivate new varieties of animals, plants and microorganisms.

Such as chemical mutagenesis, more commonly used are alkylating agents, such as ethyl methanesulfonate (EMS) and diethyl sulfate (DMS).

The method of use is very simple, dilute it to a certain concentration, and then put the seeds that need to be mutagenized into it and soak for a while.

Afterwards, the mutated seeds are germinated, and plants with the desired trait phenotype are selected, and then mutants capable of stable inheritance are selected through selfing or hybridization.

Of course, the workload of screening is huge. Taking tomato as an example, sometimes tens of thousands of seeds need to be screened to find the desired traits.

And physical mutagenesis.

The principle is to use various radiations to accelerate the mutation rate of plants, among which Gamma rays, α rays, β rays, γ rays, X rays, ultraviolet radiation, etc. are commonly used, and these operations require special equipment.

The more famous one is the laboratory of the Radiation Breeding Research Institute of Japan Benzene. They specially built a tower for radiation treatment, surrounded by an experimental field.

After some discussion, we settled on two research targets—grapes and strawberries.

These are two types of fruits commonly found in greenhouses in Sodong Province.

Just when they were about to assign tasks, footsteps came from the door of the conference room, and everyone subconsciously turned their heads to look, and it turned out that it was Zhou Wen.

"Zhou Suo is here."

"Hi Zhou."

"Hehe, everyone is here, sit down..."

Zhou Wen stretched out his hand to signal everyone to sit down, and then sat down next to Wang Hua, "What are you discussing?"

While speaking, he had already seen the research plan on the table, as well as related materials about mutagenesis technology.

Song Xuezhang, who was sitting opposite Zhou Wen, said, "We have just selected two targets..."

Following Song Xuezhang's narration, Zhou Wen's ears suddenly heard four or five mission prompts one after another.

Zhou Wen: "..."

He had never received so many tasks at once.

Open the system task and take a look, there is a long row of new tasks on the list.

[Task 1: Radiation breeding.

Requirements: Establish a grape radiation breeding research group.

Reward: 2000 subject experience, 1000 points, one chance to draw a lottery (bronze)]

[Task 2: Chemical breeding.

Requirements: Establish a grape chemical breeding research group.

Reward: 2000 subject experience, 1000 points, one chance to draw a lottery (bronze)]

[Task 3: Radiation Breeding 2.

Requirement: Establish a Strawberry Radiation Breeding Research Institute...]

The requirements of task 3 and task 4 are similar, except that the requirement is changed from grapes to strawberries.

The first few tasks, in his opinion, were the system sending points.

But the latter is more exaggerated.

For example, task 5 requires cultivating grapes with an average single grain of 50 grams.

The Fujiminori grape, the largest grape variety in China, has an average single grain of only 22-30 grams, and the largest one is only 35 grams. This has nearly doubled.

Task 6 requires cultivating a single strawberry with a maximum size of 500 grams.

This is even more exaggerated, the world record is only 231g, which is more than doubled, the system really thinks highly of him...

——

ps: Sorry, please...

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