Rebirth of the God-level Xueba

Arnold and Franky lowered their heads to discuss, and employees from other companies also gathered around, discussing and calculating in a low voice.

After reading the things in her hand, Grace looked up and saw that several people were talking in the corner, she couldn't help curling her lips, and said, "You are all doing clinical candidate assessment, there is not much difference in the assessment of each family, why not read it out loud , save some time, and let everyone devote their energy to real research."

Everyone is from a pharmaceutical company, and you can almost know what each other is doing with your chin, but there is still a big difference between a fig leaf and no fig leaf, just like your neighbor gave birth to a child, whether it is a neighbor Whether it belongs to you or your own, you don’t need to say it out—“Congratulations, the child is really yours” will not make the neighbors happy.

It's a pity that Grace is not a good neighbor. She didn't care if the others were still looking at each other, and said to herself: "The animal experiment results of deferiprone are very good, everyone can see, what's the use of you secretly counting, can Sinovel Don't you know what you did?"

"The grades are indeed very good, but the side effects are also great. We were discussing the side effects just now." Arnold lied out of his mouth.

Grace snorted and said, "It's just some gastrointestinal reactions, joint pains, mild drug allergies, liver dysfunction, zinc deficiency, weight gain, dry skin, rashes, agranulocytosis and neutropenia... some What a big deal, these are simple questions compared to the dangers faced by people with thalassemia."

Yang Rui stared, and added helplessly: "These adverse reactions are relatively mild and reversible, and are related to dosage and individual sensitivity. The most serious complication is agranulocytosis, but the occurrence rate is very low, and it is Temporary."

"Although this is the case, will FDA and other agencies think so? There are so many problems in animal experiments, and it will take a while to enter clinical trials." So far, no company has proposed acquisition or purchase plans , but at this stage, Arnold and others have consciously lowered the expectations of deferiprone.

Trading in the pharmaceutical field is very expensive, very expensive, and it is not easy to lower any point. Arnold himself is a professional in charge of negotiation in the company, and he will never let go of a word.

Grace sneered at Arnold's words, and said, "Deferiprone can be taken orally. This alone makes it a huge improvement over deferoxamine. The FDA will figure it out, if they still play golf... "

"Or the Yankees box, the same effect." The man sitting on the right said a word, followed by another: "The favorite of us Americans will always be baseball, and it will always be baseball!"

"Because your rugby is so boring." Franky used the term, in England, it's football, in America, it's rugby, and any Brit is offended by an American, or any American is offended When the British, they can be used to provoke and try everything.

The man on the right really felt the provocation, sneered, and said: "If I feel bored, I will find a woman, not a pussy."

"You are Raymond from Greenstone Corner, right?" Yang Rui didn't want a few foreigners to quarrel in the conference room of Peking University and interrupt them by standing in the middle.

"I'm Raymond, you have a good memory." Raymond was broad-shouldered and strong, with a loud voice.

"Greenstone Corner is also an original drug company, I definitely remember it." Yang Rui nodded with a smile. Compared with the well-known super pharmaceutical companies such as Pfizer,

Greenstone Corner is only a medium-sized original drug company. Even so, its annual sales are more than 2 billion U.S. dollars, and it is also a giant in other industries.

Yang Rui looked at both sides and said with a smile: "Everyone is here to learn about the animal experiments on deferiprone. Let's talk about animal experiments today. We will talk about other issues later."

"The animal experiments are perfect, so there's nothing to talk about." Grace crossed her arms and looked proudly at a group of men, almost saying "a chicken and a dog".

"You do have very beautiful data, but we haven't got all the data." The Norwegian sitting on the far right raised his head and said, but his eyes were on Grace.

Grace's Nordic ancestry is very eye-catching, and it is incomparably in line with the aesthetics of the Norwegians. They say no, but in fact they prefer this fashionable girl who mixes Nordic and British and American styles.

Grace turned a blind eye to his gaze and said, "You don't need all the data, the current results are enough for you to make an evaluation."

Arnold coughed hard, reluctant to talk about the evaluation again.

Representatives of other companies were also silent, looking down at the experimental instructions Yang Rui gave them, quietly making their own evaluations.

The meeting room suddenly fell silent.

Grace snorted dissatisfiedly, sat next to Yang Rui, and said boringly: "You should give me the enhanced version of the information now."

"It's impossible for me to take those materials out of the laboratory." Yang Rui said, "I'll show you when I get back."

"Looking at their appearance, they can't finish analyzing for an hour or two." After Grace finished speaking, she added: "You should find a good salesperson, otherwise, your deferiprone won't be sold at a good price."

"How do you know that I will definitely sell deferiprone? I can do clinical trials myself."

"Are you going to prepare 200 million dollars?" Grace looked at Yang Rui like a fool.

The US$200 million in 1984 is not a small figure, at least it is equivalent to US$400 million 30 years later. In fact, after 30 years, the financial preparations made by pharmaceutical companies for a new drug often exceed US$700 million. It’s not that it is necessary to spend so much money, but if there is not so much money, the risk of stopping because of money will be greatly increased, and investors will also lose confidence.

Yang Rui does not have 700 million US dollars, nor can he provide 200 million US dollars. Therefore, if desferiprone wants to be listed, it can only be carried out through large companies.

Yang Rui laughed twice, and said something he didn't believe: "We can go public in other countries first."

"It's just spending more money. Americans will not reduce the number and cost of your clinical trials just because your drug is on the market in other countries, and neither will Europe. Only drugs that have passed the FDA are likely to pass. Various agreements to enter the European and Asian markets.” Grace explained to Yang Rui emphatically that she did not want a good drug to fail to be marketed because of Yang Rui.

Yang Rui sighed, this is the strength of American Dad, if you don't follow his standards, you will have to spend more money, which is even more terrifying than the death penalty.

There is a business of decapitation in the world, but there is no business of losing money.

But from another point of view, although the bloated fda is inefficient, the safety of the drugs that have passed the fda is indeed commendable. Compared with the drug supervision bureaus of third world countries, the fda is still much more reliable .

"If Zeneca asks for a price, it should not be lower than 20 million US dollars." Grace said: "Deferiprone after animal experiments are completed, should be able to sell at this price."

Yang Rui smiled, not talking about the price.

Grace thought he didn't want to sell it, and said: "You sell it to a large pharmaceutical company, so that this drug can be launched as soon as possible, so that patients suffering from thalassemia can get life-saving drugs. If you want to earn money, I will It is recommended that you set up a non-profit charitable fund, of course, you can also continue to invest in laboratory research.”

"When the time comes, you have to leave." Yang Rui asked.

Grace nodded as a matter of course, and said: "Although I plan to stay in China for five years, deferiprone has exceeded the expected progress, so I have no reason to stay. The time I save is going to be used for the promotion of deferiprone. , In addition, I am also planning to raise a part of the money to support thalassemia patients who cannot afford the cost of treatment."

"Very ideal."

"Thank you." When Grace was studying, she established the idea of ​​working in a non-profit organization for life. After graduating from her Ph.D., she even rejected many high-paying jobs. The study of genetic diseases finally established the research direction of metal chelators, which are difficult to make money.

If you want to find a rational analysis, Grace may have too much "white guilt". Working in Africa, helping poor African families, and alleviating the pain of African children caused by genetic diseases, makes Grace feel sad. Easier.

Yang Rui did not comment on this. After the representatives of Zeneca and other companies had read the documents, they said: "The animal experiments on deferiprone in Huarui Laboratory are coming to an end. We welcome all companies to send representatives to the company to learn more about it. According to the situation, each company is limited to two people, and those who are interested can fill out the application later.”

"Give me an application."

"So do we."

"It's all ready." Arnold laughed twice and said, "Zelecang is not afraid of competition."

Yang Rui nodded and asked someone to send applications to everyone.

Arnold whispered to Franky in a low voice: "Check out the patents they applied for."

...