Rebirth of the God-level Xueba

Grace's appearance caused ripples in Huarui's laboratory.

There are many foreigners in Yanjing City, and there are also many people who pursue fashion, but it is not easy to see someone like Grace with a beautiful figure and unique fashion sense.

At first glance, this looks like the attire of a female soldier on the battlefield, which is a bit rough, but when you look closely, the large embroidery on the back of the jacket and the stitched leather on the legs are extremely different.

Through the window, Wei Zhenxue commented on the red-haired and blue-eyed girl without hesitation: "When I was in the village, when I saw four colors at once, I met a leopard."

"You grew up in the compound. Since when did you live in the village?" Huang Mao knew Wei Zhenxue from the bottom up, and a single sentence exposed him.

Wei Zhenxue coughed and said, "My grandma lives in the village."

"Your grandma is from the Coal Management Bureau." Huang Mao sighed, very worried about Wei Zhenxue's nonsense skills.

Wei Zhenxue coughed hard again, and said, "What's wrong with the Coal Management Bureau, the Coal Management Bureau's downfall has a hometown."

"It's fine to have a hometown, but your hometown is Da*tong, right? Are there leopards in Datong?"

Wei Zhenxue's coughing lungs were about to come out, and he said: "It's purely against me, right? Why can't our Da*tong have leopards? There is a leopard head office in our Da*tong zoo..."

After thinking about it and feeling that it didn't match what he said before, Wei Zhenxue coughed again, and continued: "The leopard from our university and the zoo ran out, and ran to our village to let me see it, okay!"

"Yes yes yes..."

"What's the problem?"

"On a."

"Say it." Wei Zhenxue was furious.

Huang Mao took two steps back and said, "Leopards only have three colors."

"What?"

"Yellow, black and white, haven't you seen them in the zoo?" Huang Mao said with a smile.

Wei Zhenxue coughed hard, coughed hard: "I was in my grandma's hometown, and I saw a leopard that ran out of the zoo. It must be four colors. Maybe it was covered with soot. Yes, it must be coal ash."

"Soot is black..." Li Wenqiang asked in a low voice.

Wei Zhenxue wished he could cough up his lungs.

In the yard, Grace was also a little worried when she heard the deafening coughing in the room, and asked, "Did any of you have the flu? Or severe pneumonia."

"No, they're playing games." Duan Bo, who went out to do research work, lied against his conscience.

"Learning the sound of pneumonia?" Grace asked with a rich imagination, "Is it a new project in your laboratory?"

"Of course not, they are just playing. Let's go to the laboratory here..." Duan Bo led the two into the laboratory with some embarrassment, and then introduced the recent work.

With her hands in her trouser pockets, Grace slipped around the main laboratory handsomely and asked, "Who is Yang Rui? I heard that he is the main researcher of deferiprone, right?"

"Yes, according to Yang Rui, he hasn't come today." Duan Bo looked at his watch and said, "He only came here at noon in the past few days. Do you want to wait?"

"Of course, I'm here to see him." Grace said, looking for a place to sit down, and said: "Go and do your work, I'll just wait for Yang Rui to come and see him by myself.

By the way, what does he look like? "

"What does it look like..." Duan Bo recalled the description suitable for Yang Rui, and replied in written language: "It looks straight, very straight."

The interpreter tentatively gave Grace an interpreter.

Grace didn't understand: "What is that?"

"I'll know when I see you." Duan Bo replied.

Two hours later, Yang Rui appeared, and Grace recognized him immediately.

"I didn't expect that there are such men in China." Grace tilted her head and watched Yang Rui walking step by step with admiring eyes.

At this time, Huang Mao was in charge of accompanying him, and he said with a strange expression: "There are all kinds of wonders in the world, China has a population of hundreds of millions, and there are all kinds of men."

Grace shook her head and said, "Impossible."

Huang Mao was surprised: "Why?"

"I know all scholars above the level of biology, and there is no such thing as Yang Rui." Grace used the adjective given by the translator just now.

The introverted Duan Bo was momentarily speechless.

Grace stared at Yang Rui for a while before asking: "It took you three weeks to make 19 derivatives of deferiprone?"

Yang Rui was also a little stunned by Grace's appearance, examined her blue eyes and high nose bridge, and said, "Are you the expert that Fan Lundin said?"

"Yes, this is Professor Grace Bryan from Cambridge." Fan Lundin suddenly sensed a deep sense of crisis, he stood directly between Yang Rui and Grace, and said: "We can save a little time for greetings and use it to understand Hua. sharp lab work on deferiprone."

"I think you mean my work." Yang Rui did not hesitate to take credit for himself, and what he said was true. In the process of developing deferiprone, except for the help of a few experimental dogs, all He does the work.

Valentin chuckled twice: "Okay, your work..."

"Can I see your experiment records? Unless it's too confidential."

"It is indeed confidential. You can see the part we screened out." Yang Rui knew that there would be people who wanted to know about his work, especially the observations of professionals. Drugs, he has no reason to disclose all the information to the other party.

"The selected part is also fine." Grace got the bound document and quickly flipped through it.

Synthesizing a compound is extremely difficult, but the molecular formula and synthesis process are as simple as hell.

"I want to ask a question." Grace put the document aside and said, "Why did you choose to make deferiprone? In terms of iron chelate, are hbed-like compounds and dft-like compounds more promising?"

"Maybe, but I think deferiprone is more realistic." Yang Rui shrugged and replied.

Grace held her chin with her hand, posed for a pose, thought for a moment and said: "If it were me, in order to make the product as soon as possible, I would choose it. Its two phenolic hydroxyl groups and the 4-position n on the triazole ring constitute three The chelation site is similar to deferiprone in terms of affinity for iron ions, but its lipophilicity is stronger, which ensures the ability to enter cells after oral absorption. No matter how you think about it, it is more realistic than deferiprone .”

Her string of words and terms instantly made the research atmosphere in the laboratory thicker, and several people looked at Yang Rui, wanting to hear his answer.

However, Yang Rui just spread his hands and said, "I'm afraid we'll have to do clinical trials to find out how lipophilicity is in the human body. Before that, it's even more difficult to synthesize, isn't it?"

Grace smiled, looked at Yang Rui with enthusiasm, and said, "You can synthesize 19 compounds of deferiprone in 3 weeks. Isn't it easy to synthesize?"

Yang Rui was stunned, these words really hit his weakness.

Synthesize 19 kinds of deferiprone compounds in 3 weeks. Even if others say that Yang Rui is fast, Yang Rui does not care. Anyway, I am fast because I am good, and you are slow because you are stupid. There is no need to say such subtext.

But Grace's question is very sharp. Since Yang Rui is so good at synthesis, why doesn't he synthesize more difficult but more effective compounds?

Moreover, Grace's vision is still very good, and in the future, she will pass the review of the Food and Drug Administration and become a powerful drug named deferasirox, which is stronger than deferiprone in terms of overall safety and efficacy. .

It is difficult for Yang Rui to explain this. He can’t say that he is very worried about the risk of kidney failure caused by deferasirox. That is a potential risk that was not discovered until two years after the launch of deferasirox. Yang Rui didn't even synthesize this drug, so how could he make a judgment.

Re-examine deferiprone and deferasirox from the perspective of future generations. The latter is still superior to the former, but the risk of renal failure is a very strong negative item. Novartis did clinical trials back then, or it passed through luck. Or it may be that the conspiracy theory has been covered up, and these uncertainties are what Yang Rui tried his best to avoid.

It took several years and finally failed in the third phase of clinical trials. No matter how you think about it, this is the rhythm of the company going bankrupt.

Not to mention Sinovel's current third-party revenue of US$10 million a year, even medium-sized pharmaceutical companies with annual revenues of hundreds of millions of US dollars often cannot afford the failure of the third phase of clinical trials.

In the field of pharmaceuticals, where investment is rising exponentially, most pharmaceutical companies will not even touch the second phase of clinical trials. They prefer to sell drugs that have passed the first phase of clinical trials at a good price, and then let large companies bear higher costs. risk and earn greater profits.

After thinking for a long time, Yang Rui replied: "The medicines made are more complicated, and the cost will be higher. I think that Chinese patients, as well as most of the ground patients, need medicines with lower prices."

"But the curative effect of the finished medicine will be better." Grace looked directly into Yang Rui's eyes.

"If we could make this expensive drug after a lot of complicated procedures ... I would still choose deferiprone, you may not have seen the Chinese patients with Diping, many of them did not use deferipramine, Even when they need deferoxamine, the high price will stop them." Yang Rui paused and said: "In China, in China at present, price is more important than curative effect, and cheap drugs can prolong the life expectancy of patients more than highly effective drugs. Longer lifespan."

Yang Rui read and learned enough information from the materials collected by the hematologist Yong Xiaodong. At the same time, he also knew the past and present lives of the patients in the domestic horizon. Therefore, his answer was true and concrete.

Grace fell into a long silence.

The laboratory also fell into a long silence.

Suddenly, Grace stretched out her hand, hooked Yang Rui's neck, and kissed him deeply.

Flaming red lips, intense and long.

"You are a true scholar and fighter, and you have a kind heart." After leaving Yang Rui, Grace said softly.

But the surroundings were still silent, so silent that it was silent.

The teenagers, young, middle-aged and old people in 1984 have never seen this kind of thing.

Even Comrade Van Lundin, an Englishman, has straight eyes, like a locust tree that has been struck by lightning.

...