I Don’t Want to Win Lying Down

Looking at Xu Mang, looking at the fruit basket in his hand, the original sympathy for him vanished in an instant, thinking about what he usually did, the anger in his heart.

The second grandfather said angrily: "Xu Mang... I told you last night, don’t be late... Why are you still late for me? Let the academician Zhong wait so long, can it be long in the future? A little memory? Haolai is also a great scientist, why is this concept of time still missing?"

"Damn..."

"I don't want to either." Xu Mang said bitterly: "When I closed my eyes and opened my eyes, I realized that I was late...Second Grandpa, I really don't blame me. Besides, I just returned to China and the time difference has not come back. Things should be right."

"..."

Faced with Xu Mang's various reasons, Grandpa Second didn't want to pursue too much, after all, the next thing was the focus.

"This is Academician Zhong, who is in charge of the Institute of Biochemistry and Cell Biology of the Academy of Sciences." Grandpa Er looked at Academician Zhong, and then said: "This is Xu Mang. The boy doesn't have a perfect shape every day. ."

Academician Zhong felt that the relationship between his old friend and Xu Mang seemed to be more reliable than expected, and he was relieved suddenly, and said with a smile: "Professor Xu Mang... the first time we met, your many deeds , I have heard a lot."

"It's all small troubles." Xu Mang said with a smile: "Academician Zhong... let's go straight to the subject, what are you going to do with me?"

"We want to use your'Xuman system' to help predict the three-dimensional structure of proteins from amino acid sequences." Academician Zhong said: "The second one is about research in the field of gene editing. We hope you can find a The new system can control DNA changes more precisely."

Xu Mang:? ? ?

what?

New...new system?

Hearing what Academician Zhong said, Xu Mang looked at him with a confused expression and said, "I remember...the most popular gene editing system is the CRISPR-Cas9 gene editing system. This system was born more than ten years ago. .. Does this need a new one?"

"Correct!"

"In fact, the CRISPR-Cas9 gene editing system has huge flaws. It is not so dexterous and often makes mistakes." Academician Zhong said: "We need to find new gene editing technologies to make up for the shortcomings of CRISPR-Cas9, as far as I know. .. No one in the world is studying this."

Xu Mang did not speak, but quietly looked at Academician Zhong to develop a new gene editing system. This is not an ordinary difficulty. At present, CRISPR-Cas9 is already the most perfect form. In fact, CRISPR is a repetitive sequence in the genome of prokaryotes. It is an immune weapon produced by the struggle between bacteria and viruses.

Simply put, viruses can integrate their genes into bacteria, and use bacterial cell tools to serve for their own gene replication. In order to eliminate the virus's foreign genes, bacteria have evolved the CRISPR-Cas9 system.

Using this system, bacteria can quietly remove viral genes from their genomes. That is to say, CRISPR-Cas9 gene editing technology is a technology for specific DNA modifications to targeted genes.

"Are there any requirements?" Xu Mang asked.

"Have!"

"Reduce the risk of off-target occurrence." Academician Zhong said: "The new system requires higher safety than the CRISPR-Cas9 system. The so-called safety is accuracy. The probability of off-target is greatly reduced to achieve greater safety."

Xu Mang smiled bitterly, and said helplessly: "The difficulty is not so big. The CRISPR-Cas9 system is recognized as the best gene editing technology in the world. It is cheap and easy to use. Relatively speaking, it is actually quite accurate. If you want to pursue higher precision, you will lose other characteristics."

"such as..."

"The new system will be very expensive." Xu Mang said: "Unless artificial intelligence is used, experiments are performed on the computer first, and then experiments are performed based on the success rate, but this requires the accumulation of a large amount of data, and I don't have data in this area. "

At this time,

Academician Zhong showed a smile: "As for data, Professor Xu Mang, you don't need to worry at all. We have a very complete database that can be disclosed to you, and you can use it at will.

I...

Come prepared!

Xu Mang opened his mouth, and finally he swallowed it again. The CRISPR gene editing technology is hailed as the most disruptive emerging technology in the 21st century, and it is also affected by various negative effects. Xu Mang is worried about the new The system will bring new panic to the world.

"What's wrong with Professor Xu Mang?" Academician Zhong saw Xu Mang wanting to say something but stopped, and hurriedly asked: "Is there any problem? If there is a problem, you can raise it in person, and we can discuss it now."

"No... nothing." Xu Mang said helplessly, "Can you give me a few days to think about it?"

"it is good!"

"I know what you are worrying about." Academician Zhong nodded and said seriously: "Professor Xu Mang...gene editing technology is not as scary as you think. In fact, gene editing technology is the most promising cure for HIV so far. A technology for heart disease and cancer."

Xu Mang smiled bitterly: "I know...I am engaged in theoretical physics. It is the easiest to subvert the world pattern, such as the mass-energy equation... Don’t worry, Academician Zhong, I am not the kind of person with very old thinking, but I I think I might not succeed."

Academician Zhong did not speak, the more this time, the less pressure Xu Mang could be given.

"Speaking..."

"If I accept, where is the work location?" Xu Mang asked curiously, "Should I go to the capital?"

"No need."

"I think the Fuda Department of Biology building is very good. It has very complete supporting facilities and does not need to come to the capital." Academician Zhong said.

"Oh..."

"Then I will go first, and I will give you an answer in a few days."

The words fell off,

Xu Mang took the fruit basket he had just brought, and left the principal’s office straight away. Faced with this situation, Grandpa Second had been familiar with it, but Academician Zhong looked confused. This... this fruit feeling was bought. Eat it yourself?

...

Xu Mang was paralyzed on the sofa alone, thinking about the new system in the field of gene editing. The new system is estimated to be impossible. The difficulty is not sporadic. In most cases, it should be optimized on the CRISPR system.

but...

The difficulty is not so big!

The CRISPR system has become a game changer in the field of biological sciences. This technology uses Cas9 specially programmed enzymes to discover, remove and replace specific parts of DNA, and it is very cheap, simple and powerful.

"Can you make a breakthrough?" Xu Mang clutched his head, feeling a little confused for a while. According to the historical process, a breakthrough can be made. After all, CRISPR technology was discovered in the early 1990s, and then seven years later. It then became the most popular gene editing tool in the fields of human biology, agriculture, and microbiology.

but...

There is a little Xu Mang wants to complain. The United States is so shameless that it secretly obtained the first patent authorization of CRISPR, which means that the future use of CRISPR technology may be illegal.

Finally stayed up until five o'clock in the afternoon,

Yang Xiaoman came home from work and saw Xu Mang lying motionless on the sofa. It was no wonder that his husband was paralyzed at every turn. He walked to the side and asked curiously: "Should you not? Did you lie down on the sofa for a day?"

"No."

"It's only half a day..." Xu Mang said with a smile, "Xiaoman... I went to see Grandpa Er in the morning. He introduced a person to me, who is in charge of the Institute of Biochemistry and Cell Biology of the Academy of Sciences. Academician Ren Zhong."

Yang Xiaoman frowned and asked indifferently: "Are you looking for help again?"

"Ok!"

"But I also want to challenge it." Xu Mang said seriously: "This is about the research direction in the field of gene editing, looking for a new editing tool system that is better than the existing CRISPR system."

Hearing Xu Mang's words, Yang Xiaoman's face was confused, and he couldn't understand what he was talking about. This guy's field is getting wider and wider, and he is all involved in the field of gene editing...

"Ugh?"

"idiot?"

"Are you engaged in physics?" Yang Xiaoman sat beside Xu Mang and asked curiously: "I found that your partial subject is getting more and more serious. You are a theoretical physicist. Can you do well? Your job?"

"Ugh..."

"It takes more work for those who are able." Xu Mang said with a smile, "Is it true?"

"Stupid!"

Yang Xiaoman gave a white glance and asked calmly, "What do you want to eat at night? I'll make it for you? Or should I have braised pork? Or... how about steamed sea bass?"

"Whatever~www.wuxiaspot.com~ As long as you make it, I love it." Xu Mang said casually, and the result was such an absent-minded sentence that made Yang Xiaoman ran into the kitchen, even if it was heavy. The cooking fume can't stop Xu Mang from cooking.

The next day,

Xu Mang lay on the bed. After a night of thinking, Xu Mang decided to contribute his own strength in the field of gene editing, trying to find new possibilities, but most likely to make some changes in the CRISPR system.

"Hey?"

"Second Grandpa..." Xu Mang said with a smile, "Guess what I want to do?"

"..."

"What do you want to do?" Grandpa Second said angrily: "How about your thinking?"

"about there."

"I'm going to try." Xu Mang said seriously: "This is a very interesting challenge, and I like to challenge, otherwise I would not marry Xiaoman."

The second grandfather suddenly became a little serious, and said to Xu Mang: "Xu Mang... are you sure you can? This is not a trifle. Once something goes wrong, the consequences will be disastrous... Should you stop thinking about it?"

"no need!"

"I have already considered it." Xu Mang said: "Accept the challenge!"

Immediately after,

The two talked about the trivial matters of life, and then hung up in a hurry.

The second grandfather took the phone and hurriedly called his old friend Academician Zhong, speaking like Xu Mang. He got off the plane early in the morning and went back at night.

"Hey?"

"Old clock!"

"Xu Mang agreed." Grandpa Second said: "The next thing, you can talk to him."

......